Bryan Johnson Blueprint Complement Stack: Why He Takes 100+ Tablets Each day

Look, I get it.

Whenever you first hear that some tech millionaire is swallowing 100+ capsules each single day and spending $2 million a yr attempting to not die, your first thought might be “this man’s misplaced it.”

However right here’s the factor about Bryan Johnson that made me dig deeper: the person’s acquired receipts. Actual knowledge. Blood work that will make your physician jealous. Coronary heart metrics of a 37-year-old at age 46. The lung capability that places 18-year-olds to disgrace.

So I spent the final three weeks analyzing each complement, each dose, each timing element of his Blueprint Protocol. Tracked down the precise merchandise he makes use of. In contrast prices. Even tried to determine which of them really matter versus which of them are simply costly pee.

What I discovered? It’s each extra excessive and extra scientific than you’d anticipate.

This isn’t some random biohacker throwing dietary supplements on the wall. Johnson’s working what quantities to a medical trial on himself – full with medical supervision, fixed biomarker monitoring, and sure, a complement invoice that might purchase a Tesla yearly. The man takes 40+ completely different compounds break up throughout three exactly timed doses: 6:45 AM with breakfast, 11 AM together with his closing meal (yeah, you learn that proper), and eight:30 PM earlier than mattress.

A few of it’s backed by stable science. A few of it’s… let’s say “optimistic.” And a stunning quantity falls someplace in that grey zone the place mouse research look promising however human knowledge is mainly “belief me bro.”

Whether or not you’re right here to repeat his total stack (please don’t), cherry-pick the good things, or simply gawk on the extremes of human optimization, I’ve damaged down every part: what he takes, when he takes it, why he takes it, and most significantly – whether or not YOU ought to even think about it.

Fast Info: Bryan Johnson’s Complement Protocol

• Complete Each day Dietary supplements: 40+ completely different compounds
• Tablets Per Day: 100+ capsules
• Estimated Month-to-month Price: $1,500-$2,000
• Protocol Began: 2021 (constantly up to date)
• Key Dietary supplements: NMN (500mg), Metformin (1000mg), Omega-3 (1600mg), Ca-AKG (2g)
• Complement Schedule: 6:45 AM, 11 AM, Earlier than mattress
• Third-Social gathering Examined: Sure (NSF-certified the place obtainable)

Desk of Contents:
Full Complement Record & Prices | Morning Stack (6:45 AM) | Afternoon Stack (11 AM) | Bedtime Stack | The place to Purchase | Is It Price It? | Finances Alternate options | FAQs

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Full Complement Record with Dosages & Prices

Complete Estimated Month-to-month Price: $1,500-2,000 (together with prescriptions)

Observe: Johnson additionally makes use of Blueprint Snake Oil (his olive oil – sure, actually) with most meals for polyphenols, although that’s technically meals, not a complement.

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Morning Stack: 6:45 AM (The Basis)

Each morning at precisely 6:45 AM, Bryan Johnson performs what is perhaps the world’s most elaborate complement ritual.

Image this: over 50 capsules lined up on his kitchen counter. A rigorously crafted breakfast ready – normally blended together with his Blueprint Collagen Peptides and Longevity Combine. The entire thing timed all the way down to the minute. It’s intense. Perhaps even obsessive. However once you see his biomarkers? You begin to marvel if he’s onto one thing.

Morning Stack Complete Injury: ~$800-1000/month

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Afternoon Stack: 11 AM (The Reinforcement)

Right here’s the place Johnson’s protocol will get bizarre. 11 AM is meal time in his world.

Yeah, you learn that proper. The person eats his final meal of the day earlier than most individuals have lunch. It’s a part of his time-restricted feeding window, which he swears by for longevity. And with this “dinner” comes spherical two of the complement marathon.

Afternoon harm: One other $400-500/month down the hatch.

Bedtime Stack: Restoration Mode

By 8:30 PM, when most of us are settling in for Netflix, Johnson’s prepping for mattress together with his closing dietary supplements:

The Weekly Wild Playing cards

Johnson doesn’t take every part each day. Some stuff cycles:

B-complex – Solely half a capsule, twice per week. Why? He’s already getting B nutritional vitamins from meals and his multivitamin. That is simply insurance coverage.

Child aspirin (81mg) 3 times weekly, not each day. Good, really. Will get the cardiovascular advantages whereas minimizing bleeding threat.

Testosterone patch (4mg/week) – Regardless of all of the optimization, his physique nonetheless wants assist sustaining hormone ranges. The patch delivers regular ranges with out the peaks and valleys of injections.

B12 injections weekly – As a result of he’s largely vegan AND takes metformin (which blocks B12 absorption). The injection bypasses the intestine totally.

The Hormone State of affairs

This deserves its personal dialogue:

Johnson takes 112mcg levothyroxine PLUS 60mg Armour thyroid each day. That’s a severe thyroid hormone alternative protocol. Both he has hypothyroidism or he’s pushing his metabolism into overdrive. Given every part else, I’m guessing the latter.

The Experiments That Failed

Not every part makes the reduce. Johnson’s discontinued listing is academic:

Rapamycin – Essentially the most promising longevity drug in animal research. Johnson tried 6mg weekly for 100 days. Stopped as a consequence of unintended effects. Even he has limits.

Human Development Hormone – 0.6mg, 5 instances per week. Additionally discontinued after 100 days. The unintended effects outweighed advantages.

17α-estradiol – Yeah, he tried taking estrogen. For science. Didn’t final lengthy.

The truth that he publishes his failures is truthfully refreshing. Most biohackers solely speak about what works.

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The place to Purchase Bryan Johnson’s Dietary supplements

Official Blueprint Merchandise

Blueprint.bryanjohnson.com

Finest Third-Social gathering Alternate options

For NAD+ Boosting (NMN/NR):

Renue by Science is the place severe biohackers get their NAD+ precursors. They provide each NMN and NR in liposomal formulations that doubtlessly soak up 5x higher than customary variations:

• LIPO NMN – Johnson’s 500mg dose in better-absorbing liposomal kind
• LIPO NR – Various to NMN, identical NAD+ advantages
• LIPO Spermidine – For autophagy activation
• LIPO Fisetin – Senolytic in liposomal kind

Use code BRAINFLOW for 10% off. All merchandise are third-party examined to 99%+ purity.

Different High quality Sources:

Finances Alternate options

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Is Bryan Johnson’s Stack Price It?

The Proof: What Bryan’s Information Exhibits

The query isn’t simply whether or not Johnson’s protocol works, however whether or not the acute value and complexity ship proportional advantages. In accordance with Colin Keeley’s evaluation and Johnson’s personal printed knowledge from his Blueprint Protocol, his outcomes are undeniably spectacular:

Organic Age Markers:

• Epigenetic age: Decreased by 5+ years
• Tempo of growing old: 0.76 (24% slower than chronological growing old)
• Coronary heart organic age: 37 (chronological age: 46)
• Pores and skin age: Mid-20s primarily based on autofluorescence
• Lung capability: Prime 1.5% for 18-year-olds
• VO2 Max: 58.7 mL/kg/min (elite athlete degree)

The information suggests Johnson has successfully reversed a number of points of growing old. His tempo of growing old rating of 0.76 signifies that for each 12 months that go, his physique ages solely 9 months. This has been verified via a number of epigenetic clocks together with GrimAge and PhenoAge. His inflammatory markers (hsCRP, IL-6) are at optimum ranges usually seen in younger adults, and his cardiovascular metrics rival these of elite athletes half his age.

Nonetheless, as famous in a number of analyses, it’s unattainable to separate the consequences of dietary supplements from his complete life-style protocol. Johnson additionally follows an especially strict eating regimen (1,977 energy each day), workout routines 60-90 minutes each morning, maintains excellent sleep hygiene (8+ hours nightly), and undergoes common medical interventions together with plasma exchanges.

Price-Profit Evaluation

When evaluating the return on funding, it’s essential to know that Johnson’s method follows the Pareto Precept – 80% of advantages probably come from 20% of interventions:

Average-Impression Dietary supplements (First rate ROI):

• NMN/NR ($50-100/month) – Promising however human research restricted – Renue by Science gives the very best worth
• Ca-AKG ($60-80/month) – Animal knowledge spectacular, human trials ongoing
• Taurine ($15-20/month) – Current longevity knowledge compelling, very secure
• CoQ10 ($30-40/month) – Particularly necessary if on statins
• Sulforaphane ($30-40/month) – Sturdy mechanistic rationale

Experimental/Costly (Questionable ROI):

1. Plasmalogens ($200/month) – Minimal human knowledge, excessive value
2. NDGA ($50/month) – Potential liver toxicity, no human longevity knowledge
3. A number of senolytics – Seemingly redundant to take fisetin + quercetin + others
4. 17α-estradiol – Johnson himself discontinued after trial
5. Prescription hormones – Require medical supervision, particular person response varies

The Hidden Prices

Past the monetary funding, Johnson’s protocol calls for vital non-monetary prices that Bryan himself acknowledges:

Time Funding:

• 30+ minutes each day organizing and taking dietary supplements
• Common blood checks and medical appointments
• Researching and adjusting protocol primarily based on new knowledge
• Sourcing high quality merchandise from a number of distributors

Way of life Restrictions:

• Should eat early (final meal by 11 AM) to optimize complement absorption
• No alcohol (interferes with many dietary supplements)
• Strict meal timing round complement schedule
• Journey turns into difficult with 100+ capsules

Psychological Burden:

• Fixed self-monitoring can create nervousness
• Danger of orthorexia (obsession with well being)
• Social isolation from excessive life-style
• Identification changing into tied to protocol adherence

Who May Profit from Johnson’s Strategy?

Based mostly on analyses from longevity consultants, Johnson’s full protocol is sensible just for particular populations:

Splendid Candidates:

• Excessive web value people ($500k+ annual earnings)
• Biohackers who take pleasure in self-experimentation
• These with household historical past of age-related illnesses
• Individuals who’ve already optimized eating regimen, train, sleep
• People with entry to common medical monitoring

Poor Candidates:

• Anybody below 30 (diminishing returns)
• These with restricted monetary assets
• Individuals who battle with fundamental well being habits
• People with consuming problems or OCD tendencies
• Anybody with out medical supervision

The Scientific Perspective

Main longevity researchers have blended views on Johnson’s method. Dr. Matt Kaeberlein, a outstanding growing old researcher, has famous that whereas particular person parts have advantage, the synergistic results of 40+ compounds are fully unknown and will theoretically embody destructive interactions.

The shortage of randomized managed trials on such complete stacks means Johnson is actually working an n=1 experiment. Whereas his biomarkers are spectacular, we can’t know:

• Which dietary supplements are literally contributing
• Whether or not there are destructive interactions
• If comparable outcomes could possibly be achieved with fewer interventions
• Lengthy-term security of this mix

The Verdict

Johnson’s stack represents absolutely the most presently doable in supplement-based life extension. For 99% of individuals, this method is neither crucial nor advisable. The proof suggests that almost all longevity advantages will be captured with:

1. Primary supplementation (D3, omega-3, magnesium)
2. Common train (Johnson’s #1 advice)
3. High quality sleep (7-9 hours)
4. Caloric restriction or intermittent fasting
5. Stress administration

As Johnson himself states in his Blueprint philosophy: “Don’t attempt to copy me precisely. Take what works in your life.” His protocol must be considered as an exploration of the doable, not a prescription for the lots.

For these impressed by Johnson however in search of a sensible method, specializing in the “Tier 1” dietary supplements he identifies as “appropriate for everybody” makes way more sense than making an attempt to duplicate his total stack. The objective must be sustainable, evidence-based interventions that improve healthspan with out compromising high quality of life or monetary safety.

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Bryan Johnson vs. Different Longevity Specialists: Stack Comparability

Understanding how Bryan’s protocol compares to different main longevity consultants helps contextualize his method. Whereas Johnson takes essentially the most complete (and costly) method, different consultants obtain spectacular outcomes with extra focused stacks.

Key takeaway: Regardless of completely different philosophies, ALL consultants take omega-3s, vitamin D3, and magnesium. Begin there.

Finances Various Stack

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Ceaselessly Requested Questions

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Medical Disclaimer

This isn’t medical recommendation. It’s documentation of 1 millionaire’s excessive self-experimentation.

Bryan Johnson’s protocol is supervised by medical professionals and tailor-made to his particular biomarkers. Don’t begin any complement routine, particularly prescription drugs like metformin or thyroid hormones, with out consulting your healthcare supplier.

What works for somebody with limitless assets and medical oversight would possibly hurt somebody with out these benefits.

Ultimate Ideas

Bryan Johnson’s complement protocol is both the way forward for human optimization or the world’s costliest placebo impact. Perhaps each.

What’s plain is that he’s pushing boundaries and sharing knowledge transparently. His Blueprint web site updates usually with new experiments, failures included. That openness is efficacious even when his protocol isn’t sensible for 99.9% of people.

For many of us, the lesson isn’t to repeat Johnson however to suppose critically about supplementation. Begin with confirmed fundamentals. Add primarily based in your wants, not mouse research. Take a look at and modify. And bear in mind – no quantity of dietary supplements can repair a foul eating regimen, no train, and horrible sleep.

Johnson’s spending $2 million a yr to possibly dwell a number of years longer. You may seize many of the advantages for below $100/month and a few self-discipline. Select properly.

Sources & References

1. Official Blueprint Protocol – Bryan Johnson
2. Bryan Johnson’s Complement Evaluation – Quick Life Hacks
3. Blueprint Complement Assessment – Jinfiniti
4. Bryan’s Morning Routine – Blueprint Weblog
5. Complete Stack Evaluation – Omre
6. Food plan & Complement Information – Colin Keeley
7. All Blueprint Merchandise – Official Retailer
8. Simplified Blueprint Evaluation – Avea Life
9. Dr. Rhonda Patrick’s Complement Record – Quick Life Hacks

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