Right here’s the factor about AOD-9604 that no one within the peptide house needs to say out loud. A pharmaceutical firm spent over $50 million creating it, ran six scientific trials on almost a thousand individuals, after which walked away.
And in some way, it’s extra common now than it ever was throughout these trials.
That disconnect is value understanding. As a result of the true story of AOD-9604 isn’t so simple as “miracle fats burner” or “failed drug.” The reality sits someplace in between, and it’s truly extra attention-grabbing than both excessive.
This information breaks down every thing. The science, the trials, what went mistaken, what the analysis exhibits, what individuals are truly experiencing, and the way it stacks up towards each different available on the market. No fluff, no gross sales pitch. Simply the total image so you may make your individual name.
What Is AOD-9604?
AOD stands for Anti-Weight problems Drug. The “9604” is only a lab designation.
AOD-9604 is a small peptide. Sixteen amino acids lengthy, snipped from the tail finish of human development hormone. It corresponds to amino acids 176 by 191 of HGH, with one necessary tweak: the primary amino acid (phenylalanine) was swapped out for tyrosine. That single change provides one further oxygen atom on an fragrant ring, and it seems to matter quite a bit for stability and organic exercise.
The peptide was invented by Professor Frank Ng at Monash College in Melbourne, Australia. Ng had spent many years finding out human development hormone and seen one thing that caught his consideration: the C-terminal fragment of HGH appeared to drive fats metabolism independently of the receptor that triggers all the opposite development hormone results.
Take into consideration that for a second. Full HGH does a ton of issues. Burns fats, builds muscle, retains water, spikes IGF-1, messes with blood sugar, grows bones. AOD-9604 was designed to isolate simply the fat-burning piece. No IGF-1 spike. No insulin resistance. No water retention. No acromegaly danger.
The industrial growth was picked up by Metabolic Prescription drugs Restricted, an ASX-listed biotech firm out of Melbourne, and so they poured critical cash into bringing it to market by the late Nineties and 2000s.
Fast Specs
The molecular weight is available in at 1,815.10 g/mol with a CAS variety of 221231-10-3. Its amino acid sequence is H-Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe-OH, and the molecule incorporates a disulfide bridge between Cys-7 and Cys-14 that provides it a cyclic form. Half-life within the blood is roughly 4 minutes (sure, actually, it really works quick and clears quick). It’s manufactured by solid-phase peptide synthesis (SPPS), then purified through HPLC.
AOD-9604 vs. HGH Fragment 176-191: They’re Not the Identical Factor
That is in all probability the one largest false impression floating across the peptide group, and it drives researchers loopy.
AOD-9604 and HGH Fragment 176-191 are totally different molecules. They get used interchangeably on boards, vendor websites, and even some clinic web sites. However they shouldn’t be.
The pure fragment (HGH Frag 176-191) begins with phenylalanine. AOD-9604 begins with tyrosine. One amino acid distinction, one further hydroxyl group. It sounds trivial till you understand that each single human scientific trial, all six of them, was carried out on AOD-9604 particularly. HGH Fragment 176-191, as famous on its personal Wikipedia web page, “has not been studied in people.”
So once you see somebody cite scientific security knowledge for “HGH Frag 176-191,” they’re truly referencing AOD-9604 knowledge. The excellence issues as a result of AOD-9604 has a selected modification designed for enhanced stability, the tyrosine substitution might have an effect on receptor interactions, and solely AOD-9604 carries the scientific trial security document. For those who’re going to make use of one, not less than know which one you’re getting.
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How AOD-9604 Works: The Mechanism (Simplified)
The mechanism behind AOD-9604 is intelligent, even when not totally mapped out at each degree. The researchers who developed it had been upfront about this. A 2014 paper by Moré and Kenley within the Journal of Endocrinology and Metabolism acknowledged that the precise receptor-level mechanism isn’t fully understood. However right here’s what the analysis has established:
It Activates Fats Burning
AOD-9604 ramps up the expression of beta-3 adrenergic receptors (β₃-AR) in fats tissue. These receptors are principally the “burn fats now” switches in your fats cells. In overweight mice, β₃-AR ranges had been suppressed. AOD-9604 restored them to near-normal ranges.
A landmark 2001 examine printed in Endocrinology by Heffernan et al. confirmed this fantastically. Overweight mice handled with AOD-9604 noticed a 216% enhance in fats oxidation charges. Once they repeated the experiment in mice genetically engineered with out β₃-AR receptors, the persistent weight reduction impact disappeared, confirming the receptor’s position. (PubMed)
It Blocks New Fats Creation
On the flip aspect, AOD-9604 inhibits an enzyme referred to as acetyl-CoA carboxylase (ACC), a key participant in de novo lipogenesis (your physique creating new fats from non-fat sources like carbs). In human fats tissue samples examined in vitro, this impact lowered glucose-to-lipid conversion by about 50%.
So that you get a two-pronged assault: present fats will get damaged down quicker, and new fats will get created slower.
What It Doesn’t Do (And This Is Key)
Right here’s the place AOD-9604 separates itself from full HGH in a extremely significant means. The complete 191-amino-acid human development hormone molecule must bind two receptor websites concurrently to activate the GH receptor. AOD-9604 solely incorporates a partial overlap with a type of binding websites and fully lacks the opposite. It bodily can’t activate the GH receptor.
Which means no IGF-1 elevation (confirmed throughout all six human trials), no blood sugar disruption (examined through oral glucose tolerance exams), no water retention, no cell proliferation issues, and no urge for food modifications such as you’d see with GLP-1 medicine. It’s working by a wholly separate, non-GH-receptor pathway.
The present principle is that HGH capabilities as one thing like a pro-hormone, a dad or mum molecule whose fragments can have their very own distinct organic results. AOD-9604 exploits a type of fragment-specific pathways.
The Scientific Trials: What $50 Million in Analysis Really Discovered
That is the half most AOD-9604 articles both skip solely or cherry-pick from. Let’s not do this. Right here’s each trial, laid out.
Animal Research: The place It All Seemed Extremely Promising
The preclinical work was thrilling. And that’s not hype.
Overweight Zucker rats given oral AOD-9604 at 500 µg/kg/day for 19 days confirmed a larger than 50% discount in physique weight acquire in comparison with controls (15.8g vs 35.6g). No detrimental results on insulin sensitivity. Printed in Hormone Analysis by Ng et al. in 2000. (PubMed)
In ob/ob mice (a genetic weight problems mannequin), AOD-9604 delivered fats oxidation will increase of over 200%. And importantly, it didn’t trigger hyperglycemia or cut back insulin secretion, each of which full HGH tends to do. (PubMed)
Fats cell research throughout mice, rats, pigs, canines, and even human tissue samples confirmed one thing attention-grabbing: AOD-9604 preferentially launched fats from overweight fats cells however didn’t have a lot impact on lean ones. That selectivity is uncommon and probably vital.
Human Trials: Six Research, Practically 1,000 Folks
Metabolic Prescription drugs ran six randomized, double-blind, placebo-controlled trials between 2001 and 2007:
METAOD001 (Part I) – 15 wholesome males, single IV doses from 25 to 400 µg/kg. Consequence: secure, well-tolerated, no points.
METAOD002 (Part IIa) – 23 overweight males, single IV doses. Consequence: no impact on IGF-1 ranges, secure.
METAOD003 (Part IIa) – 17 overweight males, single oral doses as much as 54 mg. Consequence: secure orally.
METAOD004 (Part IIa) – 36 overweight males, 7 days of oral dosing as much as 54 mg/day. Consequence: secure.
METAOD005 (Part IIb, 12 weeks) – Round 300 overweight adults, oral doses from 1 to 30 mg/day. Consequence: the 1 mg/day group misplaced 2.6 kg vs. 0.8 kg for placebo, a statistically vital distinction of about 1.8 kg (4 lbs) over three months.
METAOD006 (Part IIb, 24 weeks, “OPTIONS” trial) – 536 overweight adults, oral doses of 0.25, 0.5, and 1 mg/day for twenty-four weeks. Consequence: no statistically vital weight reduction at any dose in comparison with placebo.
The protection knowledge throughout all six trials was reviewed and printed by Stier, Vos, and Kenley within the Journal of Endocrinology and Metabolism (2013). Their conclusion was that AOD-9604’s security profile was “indistinguishable from placebo.” No critical opposed occasions, no anti-drug antibodies, no metabolic disruptions. (Full Textual content)
So… Did It Work or Not?
The sincere reply: the 12-week trial confirmed a modest however actual sign. The 24-week confirmatory trial couldn’t replicate it. Improvement was terminated in March 2007.
However the story doesn’t finish there, and that is the place context issues.
Why the Trials Failed (And Why That Would possibly Not Be the Entire Story)
4 elements converged to sink AOD-9604’s scientific program, and understanding every one is necessary in the event you’re attempting to guage whether or not the peptide has reliable potential.
1. The Life-style Intervention Drawback
The OPTIONS trial (METAOD006) required all individuals, together with the placebo group, to observe a structured food regimen and train program. That is normal in weight problems drug trials, nevertheless it creates an issue. In case your placebo group is already shedding weight from way of life modifications, there’s much less room for the drug to indicate a measurable further impact. This design selection has traditionally masked small-to-moderate drug results.
2. Oral Supply of a Peptide Is Tough
Take into consideration what you’re asking a 16-amino-acid chain to do once you swallow it as a capsule. It has to outlive abdomen acid, survive digestive enzymes, get absorbed by the intestine lining, and make it into systemic circulation. All whereas having a serum half-life of about 4 minutes.
Each scientific trial used oral supply. That’s value letting sink in.
The subcutaneous injection route, which is how nearly each clinic and researcher makes use of AOD-9604 in the present day, bypasses all these oral bioavailability points. It places the peptide instantly into systemic circulation. And right here’s the kicker: subcutaneous injection was by no means examined for efficacy in any human trial.
That is the one largest piece of context lacking from most discussions about AOD-9604. The route that failed (oral) isn’t the route individuals are utilizing. The route individuals are utilizing (injectable) was by no means examined for fats loss.
3. Species Variations in Fats Metabolism
β₃-adrenergic receptors, the important thing goal of AOD-9604’s mechanism, play a a lot bigger position in rodent fats metabolism than in human fats metabolism. It is a well-documented species distinction that has torpedoed different anti-obesity drug candidates earlier than. Rodent brown adipose tissue is wealthy in β₃-AR. Grownup human fats tissue? Not a lot.
4. The Dose-Response Curve Made No Sense
Within the 12-week trial, solely the 1 mg/day dose confirmed outcomes. Greater doses (5, 10, 20, 30 mg/day) didn’t produce larger weight reduction. That’s an inverted dose-response relationship, which is biologically uncommon and raises questions on whether or not the 1 mg consequence was a statistical fluke.
Advantages: What’s Backed by Analysis vs. What’s Anecdotal
Let’s kind the claims into tiers primarily based on precise proof.
Fats Loss: The Essential Occasion
Proof tier: Reasonable in animals, weak-to-moderate in people
The animal knowledge is strong. Constant fats oxidation will increase, weight discount, preferential motion on overweight fats cells. The human knowledge is blended: one constructive 12-week trial, one failed 24-week trial. The injectable route (which most individuals use) has zero efficacy knowledge.
That mentioned, anecdotal experiences from the group are break up about 50/50 between individuals who swear by it and individuals who noticed nothing. Extra on that locally part under.
Joint and Cartilage Restore
Proof tier: Promising however very early (animal solely)
A 2015 examine by Kwon and Park in Annals of Scientific and Laboratory Science injected AOD-9604 mixed with hyaluronic acid instantly into the joints of rabbits with osteoarthritis. The mixture confirmed enhanced cartilage regeneration in comparison with both therapy alone. (PubMed)
It’s a single examine in 32 rabbits. No human knowledge exists for joint restore. Nevertheless it’s attention-grabbing sufficient that a number of clinics now provide AOD-9604 + BPC-157 stacks particularly concentrating on joint restoration.
Muscle Preservation
Proof tier: Theoretical
AOD-9604 doesn’t work together with the GH receptor, so it doesn’t set off catabolism (muscle breakdown) or anabolism (muscle constructing). In principle, this implies fats loss with out muscle loss. However no one has truly measured lean physique mass modifications in a managed setting with AOD-9604. It’s an inexpensive inference, not confirmed knowledge.
Anti-Ageing
Proof tier: Anecdotal solely
No research. Folks extrapolate from the expansion hormone connection, however since AOD-9604 actually can’t activate the GH receptor, there’s no mechanistic foundation for conventional “anti-aging” HGH results.
Dosing Protocols
Necessary observe: What follows displays doses utilized in scientific analysis settings and people generally referenced in printed literature and group boards. That is informational context, not a advice.
What Scientific Trials Used
All trials administered AOD-9604 orally. Doses ranged from 0.25 mg to 54 mg/day. The one dose that confirmed a sign within the 12-week trial was 1 mg/day oral.
What the Analysis Neighborhood Sometimes References
The injectable protocols that dominate present use don’t have any scientific trial backing however are broadly mentioned in analysis boards. Most protocols name for 200-300 mcg/day subcutaneous as a beginning vary, with 300-500 mcg/day being normal. Weight-based steerage often breaks right down to 300 mcg for below 160 lbs, 400 mcg for 160-200 lbs, and 500 mcg for over 200 lbs.
Timing is morning on an empty abdomen. The rationale is that elevated insulin from consuming might blunt lipolytic signaling, so most protocols recommend ready 30-60 minutes earlier than consuming. Cycle size is usually 8-12 weeks on, 4 weeks off. Most clinic literature suggests anticipating 4-6 weeks for early modifications and 8-12 weeks for extra noticeable outcomes.
Reconstitution (For Lyophilized Powder)
A typical 5 mg vial reconstituted with 2.0 mL of bacteriostatic water yields a focus of two,500 mcg/mL. At that focus, 300 mcg equals 0.12 mL (12 items on a normal insulin syringe) and 500 mcg equals 0.20 mL (20 items).
Inject the water slowly down the within wall of the vial. Swirl gently, don’t shake. Peptides are fragile.
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Storage
Earlier than reconstitution, refrigerate or freeze. The powder is secure for 1-3 years frozen and as much as 2 years refrigerated. After reconstitution, hold it within the fridge at 2-8°C and use it inside 28 days. Don’t freeze the reconstituted answer, and hold it away from mild and temperature swings.
Facet Results and Security Profile
If there’s one space the place AOD-9604 shines, it’s security. Throughout six scientific trials involving roughly 925 individuals, the security profile was described as “indistinguishable from placebo.” There have been zero withdrawals or critical opposed occasions attributed to the peptide, no anti-AOD-9604 antibodies detected at any time level as much as 24 weeks, and no modifications in IGF-1, blood glucose, or insulin sensitivity. An entire battery of genotoxicity exams got here again clear (Ames check, chromosomal aberration, micronucleus assay), and persistent toxicology research ran clear by 6 months in rats and 9 months in monkeys.
(Supply: Moré & Kenley, J Endocrinol Metab, 2014)
What Customers Generally Report
Discussion board and group suggestions on uncomfortable side effects is useless constant. Most individuals report subsequent to nothing. The most typical report is gentle injection web site reactions like redness or slight itching. Some individuals get occasional gentle complications within the first week, and there are uncommon experiences of gentle fatigue or lightheadedness early on. These are inclined to resolve inside a number of days.
What It Definitively Does NOT Trigger
No GH suppression (it could possibly’t work together with the GH axis), no thyroid results, no insulin resistance (clinically examined and confirmed), no water retention, no urge for food suppression or enhance, and no temper modifications.
The Lengthy-Time period Hole
The longest human trial ran 24 weeks. That’s it. There is no such thing as a multi-year security knowledge. It is a reliable limitation value acknowledging, even given the superb short-term profile.
Regulatory Standing: The place Issues Stand in 2026
FDA Standing
AOD-9604 is not FDA authorized for any use. It by no means has been.
In December 2024, the FDA’s Pharmacy Compounding Advisory Committee (PCAC) reviewed AOD-9604 and voted towards together with it on the 503A Bulks Record. The committee cited issues about immunogenicity danger, peptide-related impurities, and restricted long-term security knowledge. (PCAC Assembly Paperwork)
Right here’s the wild half: Dr. Edwin Lee, an endocrinologist who appeared in assist of AOD-9604 at this assembly, explicitly acknowledged that “AOD9604 was ineffective for weight reduction” and “shouldn’t be thought-about as a weight reduction peptide.” His argument was for its security profile and potential cartilage/bone purposes as an alternative.
The GRAS Fantasy
You’ll see some web sites declare AOD-9604 is “FDA authorized.” That is deceptive at greatest.
What occurred was a privately convened skilled panel (not the FDA itself) decided AOD-9604 to be “Typically Acknowledged As Secure” (GRAS) to be used in meals at doses as much as 1 mg/day. It is a food-additive classification. It doesn’t represent drug approval. It doesn’t apply to injectable medicines. And the FDA’s personal actions, putting it on a security issues listing after which having their advisory committee vote towards compounding, instantly contradict any notion of broad regulatory endorsement.
Worldwide Standing
- Australia (TGA): Schedule 4 (Prescription Solely) since June 2015
- Europe (EMA): No advertising and marketing authorization
- UK (MHRA): Unapproved
- Canada: Unapproved
- WADA: Explicitly prohibited below S2 (Peptide Hormones, Development Elements). Athletes, take observe
The WADA ban has been in impact since round 2013 and was central to the Essendon Soccer Membership scandal in Australia, the place a sports activities scientist administered AOD-9604 to 34 AFL gamers.
How AOD-9604 Compares to Every part Else
One of the vital helpful issues you’ll be able to perceive about AOD-9604 is the place it sits relative to different choices. Right here’s the total breakdown.
AOD-9604 vs. Full HGH
| AOD-9604 | Full HGH | |
|---|---|---|
| The way it works | Direct fats metabolism, non-GH receptor | GH receptor activation, systemic results |
| Fats loss | Modest/variable | Confirmed, particularly visceral fats |
| IGF-1 elevation | None | Vital |
| Insulin resistance | None | Frequent with persistent use |
| Water retention | None | Quite common |
| Muscle constructing | No | Sure |
| Month-to-month price | $100-200 | $800-3,000+ |
| Authorized standing | Analysis chemical | Prescription managed substance |
The tradeoff is obvious. Full HGH is simpler however comes with a laundry listing of uncomfortable side effects, prices 5-15x extra, and requires a prescription. AOD-9604 is way gentler and cheaper however has a a lot weaker proof base.
AOD-9604 vs. Semaglutide (Wegovy) and Tirzepatide (Zepbound)
That is the comparability everybody needs proper now, and it’s not shut when it comes to uncooked efficacy.
| AOD-9604 | Semaglutide | Tirzepatide | |
|---|---|---|---|
| Common weight reduction | ~2-3% (inconsistent) | ~15% | ~20-22% |
| FDA authorized | No | Sure | Sure |
| How you are taking it | Each day injection | Weekly injection | Weekly injection |
| GI uncomfortable side effects | Minimal | Frequent (nausea, vomiting) | Frequent |
| Muscle loss concern | None | Vital | Vital |
| Month-to-month price | $100-200 | $200-1,350 | $500-1,100 |
| Urge for food suppression | None | Major mechanism | Major mechanism |
GLP-1 medicine blow AOD-9604 out of the water for pure weight reduction numbers. However in addition they include nausea that may final weeks, potential muscle loss that worries lots of people, and in lots of instances weight regain once you cease. AOD-9604’s benefits are tolerability, muscle preservation (theoretical), price, and accessibility.
Some clinics at the moment are combining AOD-9604 with low-dose GLP-1 agonists, concentrating on each urge for food suppression and direct fats metabolism concurrently. There’s no printed knowledge on this mix, nevertheless it’s changing into a talked-about protocol.
AOD-9604 vs. CJC-1295 + Ipamorelin
| AOD-9604 | CJC-1295 + Ipamorelin | |
|---|---|---|
| Mechanism | Direct fats metabolism | GH secretagogue (stimulates pituitary) |
| Scope of advantages | Fats loss primarily | Fats loss + muscle + sleep + restoration |
| IGF-1 results | None | Reasonable elevation |
| Month-to-month price | $100-200 | $200-500 |
CJC-1295/Ipamorelin is taken into account the “gold normal” peptide stack for physique recomposition as a result of it raises precise development hormone output, which advantages a number of methods. AOD-9604 is extra focused, fats metabolism solely, which is both a characteristic or a limitation relying in your targets.
AOD-9604 vs. Tesamorelin
Tesamorelin is the one peptide on this house with precise FDA approval (for HIV-associated lipodystrophy). It’s a GHRH analog that stimulates pituitary GH launch and has Part III scientific trial knowledge exhibiting actual visceral fats discount. AOD-9604 has a milder mechanism, no approval, and weaker efficacy knowledge. Nevertheless it additionally prices much less and has fewer systemic hormonal results.
AOD-9604 vs. 5-Amino-1MQ
5-Amino-1MQ is a small molecule NNMT inhibitor with a very totally different mechanism (NAD+/SIRT1 pathway). It is available in oral capsules, which is a significant comfort benefit. Nevertheless it has zero human scientific trial knowledge. AOD-9604 has extra scientific proof, even when that proof is blended. Each sit in roughly the identical month-to-month worth vary.
What Actual Customers Really Expertise
Studying by Reddit threads, peptide boards, and clinic opinions paints an image that’s extra nuanced than both the promotional materials or the skeptics recommend.
The Constructive Camp
Roughly half of experiences are constructive. Folks describe fats loss accelerating past what food regimen and train alone had been producing, with outcomes changing into notably noticeable in “cussed” areas just like the decrease stomach and love handles after 6-8 weeks. Negative effects are reported as almost zero throughout the board. Finest outcomes got here when AOD was stacked with clear consuming and constant coaching, and a few customers report improved physique composition even with out main scale modifications.
One recurring sample: individuals who had been already lean and attempting to drop the previous couple of share factors of physique fats appeared to report probably the most satisfaction. The “going from 12% to 10%” crowd tends to be happier than the “going from 25% to twenty%” crowd.
The Skeptical Camp
The opposite half is much less enthusiastic. “Ran it for two months, didn’t discover a lot of something” is a standard chorus. “The 50/50 shot” has turn into a group saying, principally flip a coin whether or not it really works for you. A number of customers identified that their outcomes may simply be attributed to the food regimen modifications they made on the similar time. A number of skilled customers had been blunt: “AOD is a type of peptides to go from 7% to six%, not 18% to 17%.” Worth-to-effect ratio got here up regularly as a priority.
The Sincere Synthesis
The group views AOD-9604 as a “possibly.” A comparatively low-cost, extraordinarily secure peptide which may offer you an additional edge in case your food regimen and coaching are already dialed in. It’s not going to rework anybody’s physique by itself. Consider it as a possible accelerator, not a substitute for the basics.
The individuals who appear happiest with it are inclined to already be in respectable form and concentrating on the final cussed fats, utilizing it as a part of a broader stack (usually with CJC/Ipa or a GLP-1), affected person sufficient to run 8-12 week cycles, and practical about expectations moving into.
No scientific knowledge exists for any of those combos. However for informational context, these are probably the most regularly mentioned protocols in analysis boards:
AOD-9604 + CJC-1295/Ipamorelin – The most well-liked combo for physique recomp. AOD within the morning fasted, CJC/Ipa at bedtime. The concept is hitting fats metabolism instantly (AOD) whereas additionally boosting pure GH output (CJC/Ipa) throughout sleep.
AOD-9604 + BPC-157 – Fashionable amongst athletes coping with accidents. BPC-157 for tissue therapeutic, AOD for fats administration. Each administered morning.
AOD-9604 + Semaglutide or Tirzepatide – An rising mixture. GLP-1 for urge for food management and main weight reduction, AOD for potential further fats metabolism assist. Some clinics are actively providing this protocol.
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Is AOD-9604 Value It? The Sincere Evaluation
Let’s minimize to it.
The proof says: AOD-9604 has an excellent security profile validated throughout almost 1,000 human individuals and a number of animal research. Its fat-loss mechanism is scientifically believable and well-documented in rodent fashions. However the definitive human weight-loss trial failed. And the injectable route everybody makes use of in the present day was by no means examined for fat-loss efficacy.
What the proof doesn’t seize: The failed trials used oral supply. The injectable route bypasses the largest limitation of oral peptide supply. It’s solely believable, and loads of researchers assume doubtless, that subcutaneous AOD-9604 performs in another way than oral. We simply don’t have the managed trial to show it.
The true-world image suggests: About half of customers report significant fat-loss advantages past food regimen and train alone. The opposite half doesn’t. Negative effects are near nonexistent both means. At $100-200/month, the monetary danger is comparatively low.
The place it suits: AOD-9604 isn’t a standalone fat-loss answer. It’s not even near what GLP-1 medicine can ship. However for somebody who’s already placing within the work, coaching exhausting, consuming proper, managing their sleep, it represents a low-risk possibility which may present an additional push. Notably for cussed fats. The protection margin is large sufficient that the draw back of “it didn’t do a lot for me” is principally the associated fee.
FAQ
What does AOD-9604 stand for?
Anti-Weight problems Drug 9604. It was the 9,604th compound in its analysis designation collection, developed as a possible pharmaceutical therapy for weight problems.
Is AOD-9604 FDA authorized?
No. It has by no means been FDA authorized for any medical use. It acquired GRAS (Typically Acknowledged As Secure) standing as a meals additive at doses as much as 1 mg/day, however this can be a meals classification, not a drug approval.
What’s the distinction between AOD-9604 and HGH Fragment 176-191?
They’re totally different molecules. AOD-9604 has a tyrosine substitution on the N-terminus that HGH Fragment 176-191 lacks. Solely AOD-9604 has been studied in human scientific trials.
Does AOD-9604 have an effect on blood sugar or insulin?
Scientific trials particularly examined this and located no impact on glucose metabolism or insulin sensitivity at any dose examined, as much as 24 weeks of use.
Does AOD-9604 enhance IGF-1?
No. This was confirmed throughout all six human trials. AOD-9604 can’t activate the GH receptor and doesn’t stimulate IGF-1 manufacturing.
Is AOD-9604 banned in sports activities?
Sure. WADA has explicitly prohibited AOD-9604 below Part S2 (Peptide Hormones, Development Elements, Associated Substances) since roughly 2013.
How lengthy does AOD-9604 take to indicate outcomes?
Neighborhood experiences usually reference 4-6 weeks for early modifications and 8-12 weeks for extra noticeable outcomes. Scientific trial knowledge from the 12-week examine confirmed measurable variations rising over the primary 3 months.
Ought to AOD-9604 be taken on an empty abdomen?
Most protocols name for morning administration in a fasted state, with 30-60 minutes earlier than consuming. The rationale is that decrease insulin ranges might optimize the lipolytic signaling pathway.
Can you are taking AOD-9604 with different peptides?
Many group protocols contain stacking AOD-9604 with different compounds. No scientific knowledge exists on combos. Anybody contemplating multi-peptide protocols ought to work with a educated healthcare supplier.
How does AOD-9604 evaluate to semaglutide for weight reduction?
When it comes to uncooked efficacy, semaglutide produces dramatically extra weight reduction (~15% vs ~2-3%). AOD-9604’s benefits are higher tolerability, no appetite-related uncomfortable side effects, no muscle loss concern, decrease price, and simpler entry.
This text is for academic and informational functions solely. AOD-9604 is a analysis peptide that isn’t authorized by the FDA for any medical use. Nothing on this article must be taken as medical recommendation. All the time seek the advice of with a certified healthcare skilled earlier than making any selections associated to your well being.
Sources
- Heffernan M, Summers RJ, et al. “The results of human GH and its lipolytic fragment (AOD9604) on lipid metabolism following persistent therapy in overweight mice and β₃-AR knock-out mice.” Endocrinology, 2001. PubMed
- Heffernan MA, Thorburn AW, et al. “Enhance of fats oxidation and weight reduction in overweight mice brought on by persistent therapy with human development hormone or a modified C-terminal fragment.” Int J Obes, 2001. PubMed
- Ng FM, Solar J, et al. “Metabolic research of an artificial lipolytic area (AOD9604) of human development hormone.” Hormone Analysis, 2000. PubMed
- Stier H, Vos E, Kenley D. “Security and Tolerability of the Hexadecapeptide AOD9604 in People.” J Endocrinol Metab, 2013. Full Textual content
- Moré MI, Kenley D. “Security and Metabolism of AOD9604, a Novel Nutraceutical Ingredient for Improved Metabolic Well being.” J Endocrinol Metab, 2014. Full Textual content
- Kwon DR, Park GY. “Impact of Intra-articular Injection of AOD9604 with or with out Hyaluronic Acid in Rabbit Osteoarthritis Mannequin.” Ann Clin Lab Sci, 2015. PubMed
- Wikipedia. “HGH Fragment 176-191.” Hyperlink
- FDA PCAC Assembly Paperwork. FDA-2024-N-4777-0009. December 4, 2024. Laws.gov
