Let’s be sincere, getting older sucks generally. You get up feeling such as you want three cups of espresso simply to really feel half as energetic as you probably did in your twenties. Sound acquainted?
Nicely, right here’s the factor: there’s this molecule known as NAD+ (nicotinamide adenine dinucleotide, should you’re into the science-y stuff) that principally acts like your physique’s mobile battery charger. And guess what? It begins draining quicker than your telephone battery after age 30.
The excellent news? Scientists have been geeking out over NAD+ dietary supplements recently, and for good cause. These little capsules may simply be the closest factor we’ve bought to a fountain of youth, minus the legendary spring water and plus some precise analysis.
7 Greatest NAD+ Dietary supplements in 2025
Right here’s my breakdown of the highest NAD+ boosters available on the market proper now:
What Can NAD+ Dietary supplements Really Do for You?
Earlier than we dive into one of the best dietary supplements, let’s speak advantages. And no, I’m not going to vow you’ll abruptly look 25 once more (sorry). However analysis is exhibiting some fairly spectacular potential:
Now, let me be clear: NAD+ dietary supplements aren’t magic tablets. However the science is getting extra thrilling by the day, with medical trials exhibiting they’re typically protected and might successfully enhance NAD+ ranges in people. Even longevity specialists like Dr. David Sinclair swear by them.
1. Greatest Total: Renue By Science Complete NAD+ Restoration Protocol
Okay, so think about if somebody took all one of the best NAD+ analysis and crammed it into one complete protocol. That’s principally what Renue did right here. (And hey, it can save you 10% on any Renue merchandise with code BRAINFLOW!)
This isn’t simply one other capsule you pop and neglect. The Complete NAD+ Restoration Protocol is just like the Swiss Military knife of anti-aging dietary supplements. You get morning tablets, night tablets, and every little thing in between, all designed to sort out NAD+ decline from a number of angles. For a deeper dive into Renue’s merchandise, try our detailed NMN overview.
What makes it particular: The protocol contains 14 totally different elements working collectively. You’ve bought your NAD+ precursors (NMN and NR), but in addition CD38 inhibitors (these cease the enzyme that eats up your NAD+ as you age), senolytics to filter zombie cells, and particular formulation for day and evening help.
The liposomal supply is clutch right here as a result of it protects the elements out of your abdomen acid so they really make it to your cells. Common dietary supplements may offer you 5-10% absorption, however liposomal? We’re speaking 90%+.
The morning components provides you vitality with out the jitters, whereas the nighttime mix helps you sleep higher and helps mobile restore whilst you snooze. It’s like having a 24/7 anti-aging group working for you.
Actual speak: Customers report feeling extra energetic inside a pair weeks, higher exercise restoration, and sharper psychological readability. One reviewer talked about feeling like they “aged backwards” after two months. The bundle really saves you about 50 bucks in comparison with shopping for every little thing individually, which is sweet.
The downsides: You’ll should be organized since this isn’t a one-pill state of affairs. And yeah, it’s expensive. However should you’re critical about complete NAD+ help, that is pretty much as good because it will get.
Get it: Store on Renue By Science with code BRAINFLOW for 10% off
2. Runner-Up: Wonderfeel Youngr™ NMN
Generally you simply need one actually good complement as an alternative of an entire protocol. Enter Wonderfeel Youngr.
This dangerous boy packs 900mg of NMN per serving, which is just like the Lamborghini of NMN doses. However they didn’t cease there. The components contains trans-resveratrol (the stuff that makes purple wine “wholesome”), olive fruit extract, ergothioneine from mushrooms, and vitamin D3. This dosing aligns with what Andrew Huberman discusses in his NMN protocol.
Why I dig it: The Harvard MD who formulated this clearly did their homework. Every ingredient has a particular job. NMN boosts NAD+, resveratrol prompts your longevity genes, ergothioneine is that this loopy antioxidant that goes wherever your physique wants it most, and the olive extract helps your coronary heart and mind.
You may take one capsule (450mg) to stretch your provide or go full throttle with two capsules. Even at half dose, you’re getting extra NMN than most opponents provide at full dose.
What customers say: Folks report higher vitality, improved focus, and a few even point out higher sleep (which appears counterintuitive for an vitality complement, however is smart when your cells are functioning higher). The resveratrol-NMN combo is especially sensible as a result of it’s like giving your longevity genes each the gasoline and the ignition swap.
The catch: At round $88 per bottle, it’s not low-cost. And the capsules aren’t enteric-coated, so a tiny little bit of NMN may break down in abdomen acid. However actually? For a single-supplement answer, that is powerful to beat.
Get it: Store Wonderfeel Youngr instantly
3. Greatest Price range Decide: Renue By Science Lipo NAD+ Full
Who says it is advisable to break the financial institution for high quality NAD+ help? This liposomal components from Renue is proof that budget-friendly doesn’t imply chopping corners. Plus, with code BRAINFLOW, you’ll save an additional 10% on prime of the already nice value!
Right here’s the kicker: this complement comprises precise NAD+ (not simply precursors), plus NMN, NR, and trigonelline. It’s like getting 4 dietary supplements in a single capsule. Most corporations keep away from placing NAD+ instantly in dietary supplements as a result of it often will get destroyed in your intestine, however Renue’s liposomal expertise protects it.
The science bit: Every ingredient takes a barely totally different path to spice up your NAD+. Having a number of precursors means your physique can use whichever pathway is working finest at any given time. The trigonelline (a particular type of B3) helps help vitality metabolism and has been proven to cut back fatigue.
At round $50-60 for a two-month provide, we’re speaking lower than a greenback a day. Evaluate that to Tru Niagen at $90 for one month, and also you see why that is our funds champion.
High quality verify: Made within the USA, third-party examined, vegan-friendly, and no bizarre fillers. Renue posts all their check outcomes on-line, which I recognize. Transparency for the win.
Minor gripes: Since every capsule splits the dose between 4 elements, hardcore biohackers may wish to take two capsules day by day. And it sells out continuously (most likely as a result of it’s such an excellent deal).
Get it: Obtainable on Renue’s website (use code BRAINFLOW for 10% off)
4. Greatest Powder Choice: Renue By Science PURE NMN Powder
Generally you need most management over your dosing, or perhaps you simply hate swallowing tablets. Both method, Renue’s NMN powder has you coated.
That is pharmaceutical-grade NMN with over 99% purity, principally as clear because it will get. At about $1.50 per gram when purchased in bulk, you’re saving critical money in comparison with capsules. Tru Niagen prices over $5 per gram, so do the maths. Don’t neglect to make use of code BRAINFLOW for an additional 10% off!
The way to use it: Combine it in water, juice, or let it dissolve underneath your tongue (sublingual crew, the place you at?). The sublingual methodology may offer you quicker outcomes because it bypasses digestion. Begin with 250-500mg day by day, although some biohackers go as much as 1 gram or extra.
Professional tip: The style is barely bitter however not horrible, form of like unsweetened inexperienced tea. Retailer it correctly (cool, dry, hermetic) and it’ll final for months. Simply don’t combine it with scorching drinks as a result of warmth can degrade NMN.
One factor to contemplate: should you’re taking excessive doses long-term, add some TMG (trimethylglycine) or a B-complex to help methylation. Excessive-dose NMN can dissipate your methyl teams, and also you wish to hold that cycle balanced.
Regardless of these minor duties, the worth right here is unbeatable. For anybody on a long life journey trying to experiment with dosages, Renue’s NMN powder is one of the best NAD complement in bulk kind. It has 1000’s of glad clients and a strong popularity within the biohacking neighborhood (Renue was previously referred to as Alive By Science, a trusted pioneer in NAD analysis). Given its purity, high quality, and cost-effectiveness, this powder is the way in which to go for NAD boosting on a funds.
Good for: DIY biohackers, anybody who needs to experiment with dosing, or people searching for the very best worth per gram.
Get it: Store instantly from Renue By Science and save 10% with code BRAINFLOW
5. Greatest NR Choice: Tru Niagen®
The OG of NAD+ dietary supplements deserves respect. Tru Niagen put nicotinamide riboside (NR) on the map, they usually’ve bought the analysis to again it up.
ChromaDex (the corporate behind Tru Niagen) holds the patent on Niagen® NR and has funded tons of research. Their analysis exhibits NR can enhance NAD+ by about 40-60% in wholesome adults. Not too shabby.
Why NR over NMN? It’s bought an extended observe report in human research and FDA GRAS standing (Usually Acknowledged As Secure). Plus, as of 2023, the FDA began questioning NMN’s complement standing, whereas NR remains to be freely offered. Politics, am I proper?
Every capsule has 300mg of NR chloride. One day by day is the usual dose, although some individuals double up. At about $90 for 90 capsules, it’s pricier than NMN per milligram, however you’re paying for that intensive analysis and high quality management.
What to anticipate: Customers report refined however actual enhancements like higher vitality, improved endurance, much less fatigue. Some point out higher pores and skin and sleep too. It’s not an vitality drink jolt; it’s extra like your cells slowly recharging over 2-4 weeks.
The NSF Licensed for Sport certification is big should you’re an athlete since each batch is examined for banned substances. Medical research have additionally proven potential advantages for blood stress and muscle metabolism.
Backside line: In order for you essentially the most researched, regulatory-approved NAD+ booster with zero sketchy elements, Tru Niagen is your jam.
Get it: Store at TruNiagen.com, Amazon, or discover it in shops
6. Greatest Quick-Performing: Quicksilver Scientific NAD+ Gold
Want outcomes yesterday? NAD+ Gold is your reply.
This liquid liposomal components is designed for pace. You pump it in your mouth, maintain for 30 seconds, and the tiny nanoparticles begin absorbing by way of your oral tissues. No ready for digestion. It’s just like the specific lane for NAD+ boosting.
Every pump provides you 50mg NMN plus 50mg TMG (for methylation help). The dose appears small, however the liposomal supply makes it punch method above its weight. Plus, analysis exhibits NMN might be transported instantly into cells for fast NAD+ manufacturing.
TMG is clutch right here: NAD+ manufacturing makes use of up methyl teams, and TMG donates them again. It’s like having a delegated driver on your mobile processes that retains every little thing balanced whereas NMN does its factor.
Customers love this for pre-workout vitality or morning mind fog. The consequences hit quick, we’re speaking 15-Half-hour as an alternative of hours. Some individuals take 2-4 pumps for a stronger impact, however begin with one and see how you are feeling.
The fact verify: At round $45 for a 30ml bottle, the fee per gram of NMN is astronomical (over $25/gram by some calculations). You’re paying for that nano-delivery expertise. Additionally, it wants refrigeration after opening and tastes… medicinal.
However if you wish to really feel NAD+ advantages ASAP, nothing else comes shut.
Get it: Quicksilver Scientific direct or approved retailers
7. Greatest with Added Synergists: Cymbiotika NMN + Trans-Resveratrol
Final however undoubtedly not least, Cymbiotika’s components is what occurs whenever you mix NAD+ boosting with critical antioxidant firepower.
Every serving packs 400mg NMN, 100mg trans-resveratrol, and right here’s the game-changer: 200mg apigenin. Most individuals haven’t heard of apigenin, however it’s this flavonoid from chamomile that inhibits CD38, the enzyme that breaks down NAD+ as we age.
Give it some thought. Most dietary supplements simply enhance NAD+. This one boosts it AND protects it from being destroyed. It’s like filling your gasoline tank whereas additionally fixing the leak.
The synergy is actual: Resveratrol prompts sirtuins (your longevity genes), NMN gives the gasoline for these genes, and apigenin makes certain that gasoline doesn’t get wasted. Dr. David Sinclair, the Harvard longevity researcher, takes the same combo.
Customers report higher exercises, quicker restoration, and enhancements in pores and skin and hair well being. The anti-inflammatory results from apigenin and resveratrol may clarify why individuals really feel so good on this.
Worth level: At $77 per bottle, it’s up there. However think about you’re primarily getting three premium dietary supplements in a single. In case you purchased NMN, resveratrol, and an apigenin individually, you’d spend far more.
The one warning: some persons are delicate to resveratrol, so take it with meals. And it’s solely obtainable by way of Cymbiotika or choose retailers, no Amazon right here.
Get it: Store Cymbiotika instantly or discover it at approved retailers
The Backside Line
Look, I’m not saying NAD+ dietary supplements will flip you right into a superhuman in a single day. However the science is legit, and these seven merchandise signify one of the best of what’s on the market in 2025.
Whether or not you go all-in with Renue’s complete protocol or hold it easy with Tru Niagen, you’re giving your cells some critical help. Simply do not forget that dietary supplements work finest when paired with the fundamentals: good sleep, common train, and never dwelling on pizza alone (belief me, I’ve tried).
Begin with the really helpful dose, give it a minimum of 4-6 weeks, and see how you are feeling. And hey, perhaps verify together with your physician first, particularly should you’re on medicines or have well being situations. Most research present NAD+ boosters are protected as much as about 1000mg day by day, however everybody’s totally different.
Right here’s to feeling youthful, pondering sharper, and having the vitality to truly take pleasure in life. As a result of what’s the purpose of dwelling longer should you don’t really feel good doing it? In case you loved this text, try our full information to one of the best NMN dietary supplements.
Sources: The analysis backing these dietary supplements retains rising. Take a look at research from Medical Information Right now, Well being.com, and up to date medical trials for the most recent. Science is cool, people!
